Indeed, the present study shows a synergistic cytotoxicity of [Flu+Clo+Bu+SAHA+Ola] in AML cells, which may be attributed to a combination of drug-induced histone modifications, decreased protein PARylation, DNA damage, increased ROS production, decreased MMP, and down-regulation of the levels of DNA repair proteins. The gene discussed is XRCC6P5; the disease is acute myeloid leukemia.