Several mechanisms following TDLN irradiation were described to explain such detrimental effect, mostly: modification of intratumoral T-cell chemoattractant chemokine signatures leading to decrease of immune cells infiltration within tumors, and especially antigen-specific CD8+ effector T cells; depletion of the “stem like” CD8+ T cell subset in both lymph nodes and tumor; decrease in epitope spreading and T-cell activation in distant lymph nodes (22–24). The gene discussed is CD8A; the disease is neoplasm.