Once T cells have infiltrated the tumor, they encounter tumor cells with radiation-induced expression or overexpression of several surface molecules and receptors, such as MHC-I molecules (10), TNF-R superfamily (11, 12) or ligands for the NKG2D receptor (13) leading to enhanced tumor cell killing by CD8+ T cells and NK cells. This evidence concerns the gene TNFRSF1A and neoplasm.