Tyr residues (Tyr705) and Serine (Ser) residues (Ser727) at the end of the STAT protein can also be phosphorylated by JAKs to activate the STAT protein and form homologous or heterologous STAT protein dimers into the nucleus to bind the promoter of corresponding target genes, thus activating target gene transcription of HSCs and participating in the development of hepatic fibrosis (38). Here, SOAT1 is linked to Hepatic fibrosis.