JAK2 and Hepatic fibrosis: found that magnesium (Mg) isoglycyrrhizinate improved high-fructose-induced liver fibrosis in rats by inhibiting JAK2/STAT3 and TGF-β1/Smad signaling by increasing microRNA-375-3p, but the effect of a direct interaction between JAK2/STAT3 and TGF-β1/Smads signaling on hepatic fibrosis in vivo needs further study (143).