TLR4 and Hepatic fibrosis: Indeed, the degree of fibrosis in mice with TLR4 mutation has been shown to be significantly reduced in the three hepatic fibrosis models of bile duct ligation (BDL), carbon tetrachloride (CCl4), and thioacetamide (TAA), indicating that the TLR4 signaling pathway is involved in the occurrence of hepatic fibrosis (89, 90).