MKI67 and adenoma: Ki67 expression increased with an increase likelihood of signet ring cell carcinoma component (Figure 4E), degree of vascular invasion (Figure 4H), T-stage (Figure 4J), N-stage (Figure 4K), and TNM stage (Figure 4L) (P < 0.05 for all), while Ki67 expression decreased with an increase in the degree of adenoma carcinogenesis (Figure 4F) and organization differentiation (Figure 4I) (P < 0.05).