In vitro: Induced G0/G1 cell cycle arrest via decreasing the expression of both cyclinD1/CDK4 and cyclin E/CDK2 in TNBC (70), decreased cell viability and proliferation, colony formation and spheroid growth on metastatic melanoma (69).In vivo: Increased the radiosensitivity of GBM, resulting in increased tumor cell death and prolonged animal survival (71), cytotoxic effects on melanoma brain metastases (69). This evidence concerns the gene CCND1 and melanoma.