In vitro: CPZ suppresses in vitro wound healing of PANC-1 GFP-K-Ras (G12V) cells and inhibits colony formation in soft agar (54).In vivo: cell-cycle arrest at the G2/M phase in rat C6 glioma cells, selectively inhibits growth and proliferation of chemo resistant glioma cells expressing COX4-1 (51). Here, KRAS is linked to central nervous system cancer.