In vitro: induces autophagy in glioblastoma multiforme (GBM) cell lines and upregulates AMPK activity (67), inhibited the viability and migration of TNBC cells (65).In vivo: Strong antiproliferative effects on B16 melanoma cells, inducing DNA fragmentation and increasing the expression of Caspase-3, a key mediator of apoptosis (68), TZ reduces growth and angiogenesis in ovarian cancer by reducing the phosphorylation of VEGFR-2 and inhibiting PI3K/mTOR signaling in xenografts (35). Here, KDR is linked to melanoma.