In vitro: Exhibits potent and specific cytotoxicity against various leukemia cell types through the activation of AMPK and the inhibition of the PI3K/AKT/mTOR pathway (60), impedes cell proliferation and triggers autophagy by elevating the levels of LC3II and p62 in human pancreatic ductal adenocarcinoma (PDAC) cell lines (62).In vivo: Reduces the growth of both mouse and human SCLC by inducing cell death (63). The gene discussed is AKT1; the disease is leukemia.