CD4 and neoplasm: The goal of these regulatory signals transported by GB-derived EVs is to manipulate oncogenic cells associated with the tumor for example microglia, myeloid-derived suppressor cells, and dendritic cells (DCs), while blocking potential anti-tumor activity in the TME by interfering with the recruitment from the periphery and activity of immune cells, including CD4+ effector T cells and CD8+ effector T cells (52).