Notably, ACADSB, OSBPL1A, and PURA are downregulated in a variety of tumors, including ccRCC, leading to disease progression (40–42), while DNTTIP1, SLC52A2, and MRGBP are upregulated in various tumors and act as pathogenic genes (43–45). The gene discussed is DNTTIP1; the disease is nonpapillary renal cell carcinoma.