ACADSB and nonpapillary renal cell carcinoma: Notably, ACADSB, OSBPL1A, and PURA are downregulated in a variety of tumors, including ccRCC, leading to disease progression (40–42), while DNTTIP1, SLC52A2, and MRGBP are upregulated in various tumors and act as pathogenic genes (43–45).