Notably, ACADSB, OSBPL1A, and PURA are downregulated in a variety of tumors, including ccRCC, leading to disease progression (40–42), while DNTTIP1, SLC52A2, and MRGBP are upregulated in various tumors and act as pathogenic genes (43–45). Here, SLC52A2 is linked to nonpapillary renal cell carcinoma.