Subsequently, the effect of TMB on the survival of ccRCC patients was compared, and the results showed that patients with high expression of TMB and high expression of TPD52L2 had the worst prognosis, and the effect of high or low TPD52L2 expression on OS of patients was not affected by the status of high or low TMB (Figures 10G, H). This evidence concerns the gene TPD52L2 and nonpapillary renal cell carcinoma.