TPD52L2, a member of the tumor protein D52 family, is abnormally high expressed in glioma, gastric cancer, breast cancer and other tumor tissues, and plays an important role in regulating the proliferation, invasion, migration, and other malignant biological behaviors of tumor cells, accelerating the malignant pathological process of tumors (6–8). The gene discussed is TPD52L2; the disease is neoplasm.