Notably, ACADSB, OSBPL1A, and PURA are downregulated in a variety of tumors, including ccRCC, leading to disease progression (40–42), while DNTTIP1, SLC52A2, and MRGBP are upregulated in various tumors and act as pathogenic genes (43–45). Here, OSBPL1A is linked to nonpapillary renal cell carcinoma.