To examine the role of GPR15 in CRC development, we used the well-characterized AOM-DSS induced colitis-associated colon cancer (CAC) experimental model to study the course of tumor formation and development in Gpr15-sufficient (Het) and Gpr15-deficient (knockout; KO) mice (17) (Figure 3A). This evidence concerns the gene GPR15 and malignant colon neoplasm.