Gpr15-Het and Gpr15-KO mice that were not treated with AOM-DSS showed no polyp formation and had similar survival rates, while C57BL/6 WT mice treated with AOM-DSS demonstrated similar disease course/severity and survival rates as Gpr15-Het mice (Figures 3C, D, 4A-C; Supplementary Figure 6C). Here, GPR15 is linked to polyp.