However, unlike the studies by Adamczyk et al., that reported a tumor promoting role of GPR15 by focusing primarily on Tregs (47), we have performed a comprehensive analysis of well-described CD45+ immune subsets, including effector T cells, regulatory T cells, NK cells, and myeloid cells, relevant to the colon cancer immune microenvironment. The gene discussed is GPR15; the disease is malignant colon neoplasm.