Interestingly, the colon polyps (LIP) in the AOM-DSS treated Gpr15-KO mice showed distinct (e.g., expansion of MDSCs) as well as shared (e.g., increased IL-17+ CD4+ and IL-17+ CD8+ T cells) immune features of human CRC with reduced GPR15 expression. The gene discussed is CD4; the disease is infectious otitis media.