Analysis of four transcriptomic datasets totalling 120 patients did not reveal significant ACE2 mRNA changes in the liver in alcoholic hepatitis (GSE28619), blood mononuclear cells (GSE119117), and the liver in HCV infection (GSE48445) or in the liver in HBV infection (GSE54747), except that treatment of patients with HCV with pegylated interferon alpha 2 (IFNA2) was associated with decreased ACE2 expression with respect to untreated patients (Fig. S17). This evidence concerns the gene IFNA2 and alcoholic hepatitis.