In addition, single-cell RNA sequencing data of five normal and five cirrhotic human livers (including NAFLD, alcohol-related liver disease, and primary biliary cirrhosis)21 revealed low levels of ACE2 and TMPRSS2 in hepatocytes, cholangiocytes, and mesenchymal and endothelial cells (Fig. S7A–C). This evidence concerns the gene TMPRSS2 and metabolic dysfunction-associated steatotic liver disease.