TMPRSS2 and primary biliary cholangitis: In addition, single-cell RNA sequencing data of five normal and five cirrhotic human livers (including NAFLD, alcohol-related liver disease, and primary biliary cirrhosis)21 revealed low levels of ACE2 and TMPRSS2 in hepatocytes, cholangiocytes, and mesenchymal and endothelial cells (Fig. S7A–C).