VWF and Cirrhosis: Interestingly, platelet adhesion was supported by plasma containing high VWF levels in a study by Lisman et al.16 However, we observed no independent association between VWF and CT (Table S13), which could be explained by a ceiling effect in patients with ACLD who have universally high VWF, although such a ceiling effect was not evident in a previous study on PFA-100 in patients with cirrhosis.17