Localisation of linear fluorescence to the dermal side (base) of salt-split skin is indicative either of EBA or a dermal-binding pemphigoid, including those that target chains of laminin proteins (e.g., laminin-332 and γ1 laminin), which have a higher association with malignancy [66] and are difficult to treat [67]. This evidence concerns the gene LAMB2 and autoimmune bullous skin disease.