OGG1 and skin neoplasm: For example, skin cancer susceptibility has been demonstrated inOGG1-knockout mice with 8-oxoG production in the genetic material of UVB-exposed epidermal cells.28TheOGG1gene encodes the 8-oxoG DNA glycosylase enzyme (OGG1) that recognizes and removes 8-oxoG, preventing future base mismatches.