● let-7 members restrict PTH secretion, whereas miR-148 members promote secretion. In CKD, the expression of parathyroid let-7 and the increase in miR-148 members may contribute to the development of SHP. Future studies may identify miRNAs as new therapeutic targets for the management of SHP, a common complication of CKD and a source of morbidity and mortality in these patients. Here, PTH is linked to chronic kidney disease.