FOXO3 and heart failure: In a recent study conducted by Sárközy et al. (2019), the researchers investigated the potential role of miR-212 and its associated targets, including FOXO3, extracellular signal-regulated kinase 2 (ERK2), and AMP-activated protein kinase (AMPK), in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) within the context of chronic kidney disease (CKD) patients.