In a recent study conducted by Sárközy et al. (2019), the researchers investigated the potential role of miR-212 and its associated targets, including FOXO3, extracellular signal-regulated kinase 2 (ERK2), and AMP-activated protein kinase (AMPK), in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) within the context of chronic kidney disease (CKD) patients. Here, FOXO3 is linked to chronic kidney disease.