● cardiac overexpression of miR-212 in CKD failed to affect its previously implicated hypertrophy-associated downstream targets. thus, the molecular mechanism of the development of LVH in CKD seems to be independent of the FOXO3, ERK1/2, AMPK, and AKT/mTOR-mediated pathways indicating unique features in this form of LVH. The gene discussed is AKT1; the disease is chronic kidney disease.