RUNX2 and stage 5 chronic kidney disease: Overexpression of miR-133a suppresses cytosolic calcification, resulting in the downregulation of RUNX2 and OCN, according to Li et al. (2022) MiR-133a, via targeting the RUNX2 gene, can directly control cytosolic calcification and play a role in the aetiology of end-stage renal disease.