● serum miR-125b levels are associated with VC severity and serve as a novel predictive marker for the risk of uremia-associated calcification progression● It demonstrate that miR-125b is involved in the osteogenic transdifferentiation of VSMCs, at least in part by targeting SP7, and implicate miRs as a novel link for the common mechanisms of vascular calcification and bone remodeling. This evidence concerns the gene SP7 and uremia.