The particular targets of miR-133 have been identified as rhoA, a protein responsible for GDP-GTP exchange and regulation of cardiac hypertrophy; Cdc42, a signalling kinase involved in hypertrophy; and Nelf-A/WHSC2, a nuclear factor implicated in cardiogenesis (Care et al., 2007). The gene discussed is NELFA; the disease is hypertrophy.