MMP2 and glomerulosclerosis: Studies have also demonstrated the therapeutic effect of BHB on glomerulosclerosis in diabetic rats, as it ameliorated glomerulosclerosis by increasing the expression level of matrix metalloproteinase-2 (MMP-2) and causing an increase in H3K9bhb at the MMP2 promoter in the kidney of diabetic rats, thus alleviating the morphological changes of glomeruli and glomerular type IV collagen content (Luo et al., 2020a).