Interestingly, ENTPD5 has also been shown to be involved in the progression of other renal diseases by Xu et al., 2023 In a mouse model of UUO-induced nephropathy, multi-point injection of AAV-ENTPD5 and AAV-SH-ENTPD5 into the renal cortex upregulated and downregulated the expression of ENTPD5, and the results showed that UUO mice with overexpressed ENTPD5 had decreased creatinine and blood urea nitrogen levels, significantly improved renal morphology, reduced renal interstitial fibrosis, and decreased tubular cell apoptosis. The gene discussed is ENTPD5; the disease is Nephropathy.