SOD2 and type 2 diabetes mellitus: Yoshio et al. found that mitochondrial oxidative stress was caused by decreased activities of superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2) in the kidneys of type 2 diabetic rats, which was associated with a decreased intracellular NAD +/NADH ratio and Sirt3 activity (Ogura et al., 2018).