SIRT1 and diabetic kidney disease: In particular, SIRT1 expression in podocytes and glomerular cells of human diabetic kidneys and the overall reduction of SIRT1 in db/db mice have been shown to accelerate DKD progression, whereas tubular SIRT1 expression mitigates diabetic glomerular injury reduction and elevates SIRT1 expression in glomerular podocytes, to attenuate DKD.