SERPINA3 and heart disorder: On the other hand, AA facilitates the secretion of Gh through the parasympathetic nervous system, leading to the suppression of cardiac fibrosis by reducing the levels of collagen I, collagen III, and Act A. While the modulation of gut microbiota by AVLE does not represent the complete pathway underlying its cardioprotective effect, it underscores the undeniable significance of targeting the gut microbiota for the treatment of cardiac diseases.