Subsequently, Gh could activate the Akt-mTOR signalling pathway by combining with hormone secretagogue receptor (Wang et al., 2017) and adjust Act A/FS imbalance to inhibit myocardial fibrosis, which further enhanced the viability of the cardiac muscle cells and inhibited the cell apoptosis, thereby protecting the cardiomyocytes from injury (Yang et al., 2018). The gene discussed is AKT1; the disease is Myocardial fibrosis.