Nevertheless, since Wang et al. excluded the onset of heart failure 3–5 weeks after NCX1 transgene overexpression (Wang et al., 2009), we conclude that the present increase of NCX1 result from the LVH in AVS or HOCM, respectively, rather than being responsible for the progression of both pathologies (Menick et al., 2013). This evidence concerns the gene SLC8A1 and heart failure.