As an illustration, it was discovered that H2S mitigated the harm to heart muscle cells caused by a lack of oxygen by diminishing the process of autophagy (Xiao et al., 2015); while in mice treated by AngII, it was demonstrated that SO2 inhibited autophagy, thereby attenuating cardiac hypertrophy as indicated by Chen et al. (Chen et al., 2016). The gene discussed is AGT; the disease is cardiac hypertrophy.