Eleven of these genes have been experimentally validated as known CRC-related SL pairs and included in the SynLethDB (Guo et al., 2016) database, namely, PPP2R1B, PSMA5, TP53, MYC, CDKN1A, MAPK3, PSMA6, PSMB6, HRAS, POLR2H, POLQ. Here, MYC is linked to colorectal carcinoma.