Eleven of these genes have been experimentally validated as known CRC-related SL pairs and included in the SynLethDB (Guo et al., 2016) database, namely, PPP2R1B, PSMA5, TP53, MYC, CDKN1A, MAPK3, PSMA6, PSMB6, HRAS, POLR2H, POLQ. The gene discussed is PSMA5; the disease is colorectal carcinoma.