Combined with the known lung cancer SL genes recorded in SynLethDB, including SL pairs recorded in the literature and SL pairs confirmed by experiments, a total of 19 genes (33.3% of the 57 CTTs genes) were confirmed to be lung cancer-related SL genes, which were DSG2, ADSL, MCM2, MCM4, MCM6, DSP, PARP1, EGFR, KRAS, PIK3CA, MAPK1, UBC, MAPK3, POLR2E, PSMC3, RELA, PSMD6, RBX1, PSMA2. The gene discussed is POLR2E; the disease is lung carcinoma.