Eleven of these genes have been experimentally validated as known CRC-related SL pairs and included in the SynLethDB (Guo et al., 2016) database, namely, PPP2R1B, PSMA5, TP53, MYC, CDKN1A, MAPK3, PSMA6, PSMB6, HRAS, POLR2H, POLQ. Here, CDKN1A is linked to colorectal carcinoma.