In addition, our study showed a strong relationship between the occurrence of CDI and extraintestinal manifestations of IBD (arthritis, osteoporosis, osteocalcin, pyoderma gangrenosum, psoriasis, and chronic pancreatitis), we found that IBD patients with at least one CDI were more likely to develop Enterocutaneous fistula than those without CDI (5.7% versus 1.1%). The gene discussed is BGLAP; the disease is clostridium difficile infection.