In 2021, Shao et al. investigated the relationship between clinicopathologic factors of OSCC and betel nut chewing, and it was also revealed that ki-67 and p53 protein are little expressed in patients with OSCC who consume betel nuts, meaning that clinicopathologic parameters such as tumor growth, malignancy, differentiation, and prognosis are significantly improved. This evidence concerns the gene MKI67 and neoplasm.