Age (< 65, 65) Gender, Histology (Adenocarcinoma, Squamous cell carcinoma, Large cell carcinoma, Undifferentiated carcinoma), T status, (T1, T2, T3), Regional lymph node status, (N0, N1, N2), Stage (I, II, III, IV), Grade (Low, Medium/high), Border of bronchus (Positive, Negative), FEV1 < 70%, Positive vessel infiltration, Positive lymphatic infiltration, Positive pleural infiltration, Chemotherapy adjuvant, Radiotherapy adjuvant, High expression of P53, High expression of caspase 3, High expression of-H2AX, High expression of Ki67. The gene discussed is MKI67; the disease is large cell carcinoma.