The expression of p-Akt, p-PI3K, p-mechanistic target of rapamycin (mTOR), Bcl-2, autophagy marker proteins such as LC3B, and the ratio of LC3B-II/LC3B-I all increased, but p-glycogen synthase kinase-3β (GSK-3β), Bax, and cleaved caspase-3 decreased significantly in the DKD model [71]. Here, AKT1 is linked to diabetic kidney disease.