A study that included 320 elderly patients diagnosed with T2DM showed that podocalyxin detected in urine is valuable for the diagnosis of early DKD in these patients, although factors such as disease duration, glycosylated hemoglobin, uric acid, and eGFR may affect the predictive ability of podocalyxin for early DKD in patients. Here, PODXL is linked to diabetic kidney disease.