APOE and early-onset autosomal dominant Alzheimer disease: At baseline, the sham treated group were older than the active treatment group (76.62±9.97 versus 68.36±7.69, p = 0.02), otherwise there were no significant differences in sex, MMSE, Alzheimer’s Disease Cooperative Study - Activities of Daily Living, APOE4 status, white matter volume or T1w/T2w between the two groups (Table 1).