TIPE2 and breast cancer: For example, in breast cancer (BC), tumor necrosis factor–α (TNF-α)–induced protein-8 like-2 (TIPE2) fosters the production of interferon-γ (IFN-γ) and TNF-α by NK cells, enhances the killing ability of NK cells to BC cells, and hampers the development and metastasis of BC [6].