With the development of Gpr88 KO mice, Meirsman and collaborators showed a role for GPR88 expressed in adenosine A2A receptor /D2 receptor‐expressing striatal neurons in increasing trait anxiety‐like behaviours without affecting other associated behaviours such as conflict anxiety and fear (Meirsman, Le Merrer, et al., 2016; Meirsman, Robe, et al., 2016). The gene discussed is ADORA2A; the disease is Anxiety.