Given the well‐defined role for the striatum in AUD and the emerging research on striatal GPR88 contribution to behaviours such as poor motor coordination, impaired cue‐based learning, and hyperactivity in both rodents (Logue et al., 2009; Maroteaux et al., 2018; Quintana et al., 2012) and humans (Alkufri et al., 2016), it comes with no surprise that GPR88 activity in this brain region might be important for the development and maintenance of addiction‐like behaviours associated with alcohol use. This evidence concerns the gene GPR88 and alcohol dependence.