Consistent with our previously published results, mushroom supplementation with Coriolus biomass resulted in up-regulation of the inducible isoforms of both Hsp70, heme oxygenase-1 (HO-1), as well as γ-GC ligase and thioredoxin, determined in lymphocytes (Fig. 3A-F), as compared to untreated group of MD patients or healthy controls. Here, HMOX1 is linked to Menkes disease.