CD81 and hepatocellular carcinoma: Antibodies of SR-BI, CD81, claudin-1, and E2 glycoprotein dramatically inhibited infection of hCMEC/D3 cells, demonstrating that cellular CD81 and virus-associated ApoE have a role in the transmission of virus between HBECs, and a receptor-dependent entry route similar to that found in hepatocytes and cell lines derived from hepatocellular carcinoma [243, 244].