Right atrial cardiomyocytes showed higher NLRP3 inflammasome activity in patients with paroxysmal and chronic atrial fibrillation compared with the control group (which comprised individuals with a normal sinus rhythm).137 A selective inflammasome inhibitor (MCC950) blocked AF induction by preventing NLRP3 inflammatory complex formation. This evidence concerns the gene NLRP3 and atrial fibrillation.