In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibitors of the m6A methyltransferase METTL3 induced a formation of immunostimulatory double-stranded mRNAs (dsRNAs) in cancer cells, which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+ T-lymphocytes. The gene discussed is METTL3; the disease is neoplasm.