METTL3 and cancer: Importantly, CRISPR screening further confirmed that the effectiveness of METTL3 inhibition in eradicating cancer is heavily reliant on tumor’s intrinsic capability to detect dsRNA through RIG-I, OAS3, RNAse-L, PKR, and IFIH, along with a functional JAK/STAT signaling pathway and an intact MHC-I antigen presentation.