Other studies have found that dormant BCSCs regulate the abnormal expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkb3) in BCSCs when the expression of autophagy-associated protein 7(ATG7) ATG3 or P62/sequestosome-1 is low, which leads to reactivation of the proliferation program and metastatic growth, promoting BC metastasis [16]. Here, SQSTM1 is linked to breast cancer.