It widely colonizes the intestinal tract and has a role in biological barriers, enhancing immune function and exerting an anti-tumor role.19 Recent studies have demonstrated that Bifidobacteria can have a therapeutic role in various inflammatory diseases, suggesting its potential effect in regulating the inflammation response of the host.20,21 In the previous study, we found that Bifidobacterium breve (B. breve) could interact with intestinal dendritic cells (DCs),19 which are an important endogenous cellular source of interleukin-10 (IL-10), a well-known anti-inflammatory factor.22 The gene discussed is IL10; the disease is neoplasm.