IL10 and neoplasm: Our previous studies suggested that after oral administration of probiotics, the intestinal environment-immune cell interaction regulates the immune state and reduces the tumor burden.19 IL-10 is an anti-inflammatory cytokine that helps regulate the immune response, reinforcing skin wound healing and functional recovery after a brain or spinal cord injury.45–48 We found that oral administration of B. breve could promote intestinal DCs to secrete IL-10, reduce the inflammatory state of the oral mucosa, and improve oral mucosal healing under sunitinib treatment (Fig. 8).