CD68 and non-small cell lung carcinoma: Using multispectral images of Siglec-15, Pan-CK, and CD68, we divided NSCLC samples into four groups according to their Siglec-15 positivity patterns (Fig. 1A): TC-Siglec-15+ and Mφ-Siglec-15+, TC-Siglec-15+ and Mφ-Siglec-15−, TC-Siglec-15− and Mφ-Siglec-15+, TC-Siglec-15− and Mφ-Siglec-15−, and we identified patients with positive Siglec-15 expression on macrophages or TC as Siglec-15+.