CD274 and neoplasm: Figure 3B showed that Siglec-15 is mainly expressed by macrophages and that Mφ-Siglec-15 expression is independent of PD-L1 expression (p < 0.05; Fig. 3D, E), and we revealed that Siglec-15 expressed on TAMs showed more important prognostic value than that expressed on tumor cells in previous study [17], thus we further analyzed the effect of Mφ-Siglec-15 and PD-L1 expression on the prognosis of patients.