SHISA5 and cardiomyopathy: Lakota and colleagues have previously described the upregulation of SHISA5 in mesenchymal stem cells (MSCs) transplanted into human subjects with ischaemic cardiomyopathy and controls and postulated that SHISA5 contributes to the death of cardiomyocytes via apoptosis after ischaemia–reperfusion injury47,48.