H&E, Ki67, and cleaved/active caspase 3 staining on one tissue from the control group and the SPESN38-8 treatment groups with tumor tissue or mouse scar tissue were shown in Fig. 9B. On the left panel, the control tumor tissue displayed high cancer cell density with large nuclei and high Ki67 but low cleaved caspase 3 levels. This evidence concerns the gene CASP3 and cancer.