Of note, we observed increased levels of TNFα, granzyme β, and IFNγ in cell culture supernatants after treatment (Schematic representation shown in Supplementary Fig. 10A) with nanoparticles versus free BTZ (p < 0.01 for free BTZ vs. BCMA-BTZ-NP in both MM cell line). The gene discussed is IFNG; the disease is Miyoshi myopathy.