The group of anterior-dependent/deep-dependent genes (612), upregulated in AD- versus PD-CTGs, included as major functions (1) cell migration, more specifically eosinophil and lymphocyte migration, (2) cellular responses to chemokines including regulation of extracellular signal-regulated kinases (Erk) cascades, G protein-coupled receptor binding and activity, cellular responses to interleukin-1 (IL-1) and tumor necrosis factor (TNF), (3) blood vessel remodeling, (4) cell adhesion, and (5) epithelial cell function, more specifically regulation of epithelial cell proliferation (Fig. 4a). The gene discussed is TNF; the disease is Alzheimer disease.