High glucose exposure increases the O-GlcNAcylation of ZEB1, transcriptionally inducing fatty acid synthase (FASN) and fatty acid desaturase 2 (FADS2) expression, thereby resulting in ferroptosis in mesenchymal pancreatic cancer cells.207 These results indicate that glycolipid metabolism and O-GlcNAcylation play a novel role in increasing ferroptosis susceptibility in mesenchymal cancer cells, which reveals a new molecular mechanism of ferroptosis and suggests a therapeutic strategy for refractory pancreatic cancers. Here, ZEB1 is linked to familial pancreatic carcinoma.