PHGDH and neoplasm: PHGDH interacts with the RNA-binding protein poly(rC)-binding Protein 2 and inhibits its ubiquitin-mediated degradation, which in turn upregulates SLC7A11 and inhibits ferroptosis, thereby promoting malignant progression.153 The PHGDH inhibitor NCT-502 enhances ferroptosis and halts tumor progression in BCa.153 This finding indicates that inhibition of PHGDH could be a therapeutic strategy for BCa.