TP53 and non-small cell lung carcinoma: Non-small cell lung carcinoma: Regulation of ferroptosis by P53 was first reported in 2015, and the associated study revealed SLC7A11 as a direct target gene of P53 for suppression.174 The acetylation-defective mutant p533KR was found to be unable to induce cell cycle arrest, senescence and apoptosis but retained the full ability to inhibit SLC7A11 expression and induce ferroptosis.