SLC2A1 and colorectal carcinoma: AA supplementation restores the ferroptosis sensitivity of intestinal-type GCs.190 In CRC, increased methylation levels of solute carrier family 2 member 1 (SLC2A1) greatly inhibit autophagy and ferroptosis, resulting in immunosuppression and a poor prognosis in patients.191 Aberrant methylation of the promoter inactivates PCDHB14 in HCC patients.