Hepatocellular carcinoma: AKT activated by insulin-like growth factor 1 receptor (IGF1R) signaling phosphorylates creatine kinase B (CKB) at T133, reducing its metabolic activity and increasing its binding to and phosphorylation of GPX4 at S104, which prevents HSC70 binding to GPX4, thereby abrogating degradation of GPX4 by chaperone-mediated autophagy, inhibiting ferroptosis and promoting tumor growth in mice.164 Elevated expression of ribonucleotide reductase regulatory subunit M2 (RRM2) inhibits ferroptosis in HCC cells. This evidence concerns the gene GPX4 and neoplasm.