OTUB1-mediated deubiquitination rescued CCl4-triggered ubiquitination of SLC7A11, thus stabilizing SLC7A11 to activate system XC− and thereby preventing hepatocyte ferroptosis.445 The overexpressed ubiquitin E3 ligase HUWE1 inhibits ferroptosis by targeting TfR1 for ubiquitination and proteasomal degradation in the context of CCl4-induced liver injury, suggesting that HUWE1 functions as an inhibitor to mitigate ALI by antagonizing both aberrant iron accumulation and ferroptosis.446. The gene discussed is HUWE1; the disease is injury.