Bufotalin induces ferroptosis by facilitating the ubiquitination and degradation of GPX4 in NSCLC.538 Sanguinarine triggers ferroptosis by destabilizing GPX4 by promoting its ubiquitination and degradation mediated by its E3 ligase STUB1 in NSCLC.539 Selenite induces ferroptosis by activating the p38-ATF4-DDIT3 axis. The gene discussed is ATF4; the disease is non-small cell lung carcinoma.