ALZ003 significantly inhibits glioblastoma cell survival by inducing ferroptosis.545 Paeoniflorin inhibits glioma growth by inducing ferroptosis through upregulation of NEDD4L to mediate STAT3 ubiquitination-mediated repression of Nrf2 and GPX4 in glioma.546 Myrislignan induces ferroptosis through the Slug-SLC7A11 axis by inactivating NF-κB signaling through blockade of p65 phosphorylation in GBM cells.547. Here, NEDD4L is linked to central nervous system cancer.