BAP1, which encodes a nuclear DUB to reduce histone 2A ubiquitination (H2Aub) on chromatin, reduces the H2Aub level in the SLC7A11 promoter and suppresses SLC7A11 expression in a deubiquitination-dependent manner, leading to inhibition of cystine uptake, LPO and ferroptosis.149 BAP1 inhibits the progression of tumors partially by inducing ferroptosis through suppression of SLC7A11 expression, and cancer-associated BAP1 mutants lose their ability to suppress SLC7A11 and promote ferroptosis. The gene discussed is BAP1; the disease is cancer.