DHA promotes PEBP1 protein expression through inhibition of its ubiquitination and degradation.535 Polyphyllin VI induces ferroptosis by inhibiting STAT3 phosphorylation, which inhibits GPX4 expression in HCC.536 Anisomycin activates p38MAPK to induce ferritinophagy through the phosphorylation of histone H3 on serine 10 (p-H3S10) in HCC.537. This evidence concerns the gene STAT3 and hepatocellular carcinoma.