GPX4 and cancer: LINC00239 interacts with and binds to the Kelch domain of Keap1, thereby inhibiting the ubiquitination of Nrf2 to stabilize it, suggesting that LINC00239 functions as an oncogene by inhibiting ferroptosis by binding to Keap1 and stabilizing Nrf2 in CRC cells.138 Loss of ribonucleotide reductase subunit M1 (RRM1) destabilizes p53 and increases the sensitivity of different types of cancer cells to ferroptosis by inhibiting the expression of GPX4.