Berberine attenuates liver fibrosis in mice by inducing ROS-mediated HSC ferroptosis.592 Recombinant FGF21 inhibits liver fibrosis by inhibiting hepatocyte ferroptosis through promotion of HO-1 ubiquitination and degradation and Nrf2 activation.593 Artemether alleviates liver fibrosis in vivo and in vitro by inducing HSC ferroptosis through inhibition of IRP2 ubiquitination, thereby inducing an increase in the iron content in HSCs.594. The gene discussed is IREB2; the disease is Hepatic fibrosis.