Gu and colleagues revealed the role of acetylation in modulating P53-mediated ferroptosis and tumor suppression in NSCLC.175 Expression of P533KR efficiently inhibited tumor growth, which was restored by the overexpression of SLC7A11 in vivo, suggesting the important role of SLC7A11 inhibition in p53-mediated tumor suppression. This evidence concerns the gene SLC7A11 and neoplasm.