Inhibiting USP14 suppresses H/R-induced ferroptosis in HK-2 cells.490 TRIM21 aggravates ischemia/reperfusion-induced AKI by promoting ferroptosis via ubiquitination of GPX4.491 Inhibiting USP7 attenuates RIRI through ferroptosis inhibition by decreasing the ubiquitination of TBK1 and promoting DNMT1-mediated methylation of FMR1.492. Here, GPX4 is linked to acute kidney injury.