Ablation of TRIM7 increases the sensitivity of human glioblastoma cells to temozolomide, suggesting that TRIM7 functions as a negative regulator of ferroptosis.146 Downregulated expression of Rho family GTPase 1 (RND1) predicts a better prognosis in patients with glioblastoma multiforme (GBM). The gene discussed is TRIM7; the disease is glioblastoma.