JUN and hepatocellular carcinoma: An overabundance of O-GlcNAcylated c-Jun conversely inhibits ferroptosis by increasing the synthesis of GSH via increased transcription of PSAT1 and CBS.205 This observation indicates that O-GlcNAcylated c-Jun is at the core of ferroptosis and that targeting c-Jun O-GlcNAcylation might be a potential therapeutic approach for HCC.205 O-GlcNAcylation stabilizes and enhances the expression of YAP, which plays a pivotal role in controlling ferroptosis.