GPX4 and cystic fibrosis: C646 attenuates ferroptosis by inhibiting p53 acetylation in H9c2 myofibroblasts.416 Treatment of SIRT3-cKO mice with ferrostatin-1 was found to lead to significant reductions in ferroptosis and CF.416 Ferrostatin-1 increases the antioxidant capacity of cardiac fibroblasts, reduces GPX4-mediated ferroptosis and alleviates I/R-induced CF.417