Erastin promotes the nuclear translocation of USP7 by increasing its interaction with p53, which erases the monoubiquitination of lysine 120 on histone H2B (H2Bub1) in the SLC7A11 gene regulatory region and inactivates SCL7A11 expression, eventually leading to ferroptosis in NSCLC cells.142 TRIM6 functions as an oncogene by promoting SLC1A5 ubiquitination and degradation, thereby inhibiting glutamine import, glutaminolysis, LPO, and ferroptosis.143 USP35 is upregulated in NSCLC. Here, LPO is linked to non-small cell lung carcinoma.