The related study provided the first evidence that O-GlcNAcylation can increase the sensitivity of HCC cells to ferroptosis via YAP/TFRC, highlighting new therapeutic strategies for HCC.206 In pancreatic cancer, O-GlcNAcylation of zinc finger E-box-binding homeobox 1 (ZEB1) enhances ferroptosis in mesenchymal pancreatic cancer cells. This evidence concerns the gene TFRC and familial pancreatic carcinoma.