Elevated SENP1 expression mediates A20 SUMOylation to reduce the expression of ACSL4 and induce the expression of SLC7A11, thereby inhibiting ferroptosis in lung cancers.214 SENP1 functions as a ferroptosis suppressor, as determined through a novel network analysis of how A20 SUMOylation links SLC7A11 and ACSL4 in lung cancer cells. The gene discussed is ACSL4; the disease is lung carcinoma.