PAQR3 suppresses cell proliferation and aggravates ferroptosis by increasing ubiquitin-dependent degradation of Nrf2 in ALL cells.154 Activation of autophagy was found to sensitize ALL cells to Erastin-induced ferroptosis by inhibiting ubiquitination-dependent degradation of VDAC3 mediated by the E3 ligase FBXW7,155 indicating that autophagy activation combined with ferroptosis induction is a potential therapeutic strategy for ALL. Here, NFE2L2 is linked to acute lymphoblastic leukemia.