The distribution of the different serum M-components per diagnostic category was as follows: MGUS, 24/55 subjects (43%) had an IgG M-component, 18/55 (33%) were IgM, 11/55 (20%) IgA and 2/55 (4%) LC cases; SMM, 7/12 (58%) IgG, 3/12 (25%) IgA, 1/12 (8%) LC and 1/12 (8%) IgG plus IgM subjects; and, SWM, 8/8 (100%) IgM cases per definition (Supplementary Table 2). This evidence concerns the gene CD40LG and laryngotracheoesophageal cleft.