PRDM16 and chronic kidney disease: Compared with other forms of CKD, DKD has unique features.[2, 3, 4] Especially, at the pathological level it is surprising that renal tubulo‐interstitial fibrosis (TIF), a common characteristic of CKD, does not develop significantly until the late stage of DKD.[2, 3, 4, 7] In the current study, we demonstrate that PRDM16 is up‐regulated in renal tubular cells at the early stage of DKD and plays an important role in suppressing TIF development.