PRD1‐BF1‐RIZ1 homologous domain‐containing protein 16 (PRDM16) is a zinc‐finger transcription factor originally cloned from a chromosomal translocation in patients with acute myeloid leukemia and myelodysplastic syndrome.[8] PRDM16 is a strong driver of brown/beige fat biogenesis.[9, 10, 11, 12, 13] Interestingly, PRDM16 has been implicated in adipose tissue fibrosis.[14, 15] The role and regulatory mechanism of PRDM16 in renal pathophysiology including DKD and renal fibrosis is currently unknown. The gene discussed is PRDM16; the disease is acute myeloid leukemia.