TGF‐β signaling is a major driving force in renal fibrosis.[39] Upon ligand binding, TGF‐β receptors are activated and phosphorylate downstream signal transducers, especially Smad proteins, which accumulate in the nucleus to transactivate a variety of pro‐fibrotic genes.[39] There are scattered reports about the connection between PRDM16 and TGF‐β signaling. This evidence concerns the gene TGFB1 and renal fibrosis.