MAPK3 and diabetic kidney disease: Our observation of the involvement of P38 and ERK1/2 signaling in DKD is consistent with previous reports.[33, 34] In addition, previous studies reported that P38 and ERK1/2 signaling mediated TGF‐β1 expression during high glucose incubation of bone marrow stem cells and peritoneal mesothelial cell.[35, 36] However, our observation of negative regulation of MAPKs by TRPA1 is at discrepancy with published work.