In various cancers, HIF‐1α acts as a transcriptional activator and promotes the expression of genes for proliferation, metastasis, invasion, and angiogenesis by recruiting co‐activators such as p300/CBP acetyltransferases.[53, 54] In contrast, reports of HIF‐1α as a transcriptional repressor are less common. This evidence concerns the gene HIF1A and cancer.