It is established that HIF‐1 activation can promote cancer cell migration and invasion by activating the transcription of genes encoding the proteases MMP2, VEGF, and Angiopoietin‐like Protein 4.[44] EZH2 contributes to cancer development by regulating cell cycle progression and promoting cell invasion in many cancers.[45] To investigate the effect of DYB‐03 on the proliferation of NSCLC, we performed colony formation assays. Here, MMP2 is linked to cancer.