GBA1 and Gaucher disease: Gaucher disease (GD) is the most common LSD and is caused by mutations in the lysosomal glucocerebrosidase gene GBA1, resulting in the deficiency of enzyme activity; lysosomal glucocerebrosidase normally hydrolyzes the glucose moiety from glucosylceramide (GlcCer) in lysosomes (Brady et al., 1965; Stirnemann et al., 2017).