CD4 and colorectal carcinoma: We identified 258 DEPs by paired t test (fold change >1.5 or <0.67; p < 0.05) in CRC pairwise, among which 115 proteins were upregulated and 66 proteins were downregulated in CD4+ T cells (Fig. 1C); and 35 proteins were upregulated and 64 proteins were downregulated in CD8+ T cells (Fig. 1D).