A previous proteomic analysis and ingenuity pathway analysis (IPA) of blood EVs also identified four neuron- or oligodendrocyte-derived EV marker proteins, including syntaxin binding protein 1 (STXBP1), neuronal membrane glycoprotein M6-a (GPM6A), PH and SEC7 domain-containing protein 2 (PSD2) and Rho GDP-dissociation inhibitor 1(GDI1).51 Thus, a combination of these isolation technologies for brain cell-derived EVs and detection of EV-CatB could allow more sensitive and specific monitoring of AD pathogenesis in the future. This evidence concerns the gene PSD2 and Alzheimer disease.