The transition from A−T−N− to A+T−N−/A+T−N+ corresponds with Aβ pathogenesis, and the transition from A+T−N− to A+T+N+ corresponds with tau pathogenesis.19 Thus, we successfully identified several unique proteins as potential biomarkers to distinguish pathological stages of AD, possibly reflecting their involvement in brain cell pathological changes. This evidence concerns the gene MAPT and Alzheimer disease.