While analyzing the expression level of BER/SSBR proteins in publicly available transcriptomic databases of SARS-CoV-2 infected patients, we observed that the expression level of NEIL2, an oxidized base-specific DNA glycosylase, is significantly lower within the lungs of patients suffering from severe COVID-19, compared to those of uninfected individuals or even those patients with milder COVID-19 symptoms. This evidence concerns the gene NEIL2 and COVID-19.