We then found that 9/13-HODEs upregulated several genes attributed to hepatic steatosis, including fatty acid synthase (Fasn), thyroid hormone responsive (Thrsp), CD36 molecule (Cd36), cytochrome P450, family 4, subfamily a, polypeptide 14 (Cyp4a14), mannoside acetylglucosaminyltransferase 1 (Mgat1), monoacylglycerol O-acyltransferase 2 (Mogat2), and ELOVL fatty acid elongase 6 (Elovl6)15,32–35 (Fig. 3h). This evidence concerns the gene THRSP and fatty liver disease.