DUSP4 and neoplasm: Our work uncovers a novel mechanism by which ARID1A regulates DUSP4 expression and subsequent MAPK activity, highlighting the diverse mechanisms how ARID1A protein controls tumor development.  However, additional research is needed to further elucidate the signaling pathway cross talks orchestrated by ARID1A  in endometrial cancer and to determine the clinical benefit by targeting the ARID1A-DUSP4-MAPK axis.