Autophagy inhibition, indeed, increases the sensitivity of solid tumors (e.g., melanoma and CRC) to ICIs by enhancing tumor-infiltrating tumor T cells (both CD8+ and CD4+) as well NK cells and other innate immune cells (e.g., DCs, M1 macrophages) in immunocompetent mice [166, 190]. This evidence concerns the gene CD8A and melanoma.