Research has confirmed that in a silica-induced pulmonary fibrosis model, human umbilical cord MSC-derived extracellular vesicles (HucMSCs-EVs) could transfer miR-223-3p to alleviate pulmonary fibrosis by inhibiting the circPWWP2A/miR-223-3p/NLRP3 axis. This evidence concerns the gene NLRP3 and pulmonary fibrosis.