IRS1 and osteosarcoma: The correlation between RP11-414H17.5 and osteosarcoma metastasis-related genes was then analyzed and the results can be seen in Fig. 11E. It was demonstrated that RP11-414H17.5 had a positive correlation with osteosarcoma metastasis-promoting genes, e.g., ALDOA, EZH2, IRS1, etc., and negatively correlated with the gene TNFSF10, which inhibits osteosarcoma metastasis.