CLOCK and central nervous system cancer: Chi et al. [68] built a prognostic prediction model of circadian rhythm-related genes for accurately predicting the prognosis and immunological status of head and neck squamous cell carcinoma patients; Wang et al. [60] found that biological clock gene expression dysregulation promotes glioma progress through impacting the tumor immune landscape; Sun et al. [69] constructed a circadian rhythm-associated prognostic prediction model for hepatocellular carcinoma, which guided immunotherapy and chemotherapy strategies for hepatocellular carcinoma patients.