It was concluded that many immune cells aggregated in the H-R cohort, including myeloid dendritic cells, T cell CD8+, and neutrophil in TIMER, cancer-linked fibroblast and macrophage in MCPCOUNTER, T cell CD4+ Th2 and Monocyte in XCELL (all P < 0.05) (Fig. 10a). Here, CD4 is linked to cancer.